Endotoxin (lps) Neutralization by Innate Immunity Host-defense Peptides: Peptides’ Properties and Plausible Modes of Action
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چکیده
ENDOTOXIN (LPS) NEUTRALIZATION BY INNATE IMMUNITY HOST-DEFENSE PEPTIDES: PEPTIDES’ PROPERTIES AND PLAUSIBLE MODES OF ACTION Yosef Rosenfeld, Niv Papo and Yechiel Shai* Department of Biological Chemistry. The Weizmann Institute of Science Rehovot, 76100 Israel. Running title: Endotoxin neutralization by innate immunity peptides Addresse correspondence to Yechiel Shai, Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, 76100 Israel. Tel: 972-8-9342711; Fax: 972-8-9344112, e-mail: [email protected]
منابع مشابه
Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action.
Binding of lipopolysaccharide (LPS) to macrophages results in proinflammatory cytokine secretion. In extreme cases it leads to endotoxic shock. A few innate immunity antimicrobial peptides (AMPs) neutralize LPS activity. However, the underlying mechanism and properties of the peptides are not yet clear. Toward meeting this goal we investigated four AMPs and their fluorescently labeled analogs. ...
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تاریخ انتشار 2005